Posted Comments for Paper of May 1

Subject	Sender	Date
Preconditioning	Guest	May 6
Preconditioning....response	Adel Elmoselhi	May 12
.

Preconditioning by Guest
What is preconditioning and what aspects of preconditioning are critical here?
Preconditioning - response by Adel Elmoselhi
The classical ischemic preconditioning was described by Murry et al, in 1986
as few episodes or even one short period of total ischemia followed by
complete reperfusion can lead to myocardial protection against a greater
substantial ischemic insult with less possibility of infarction. Other
variations, however, have been described to achieve preconditioning such as
partial coronary occlusion (rather than total), or following beta-adrenergic
stimulation or following cycles of calcium depletion and repletion.
Preconditioning was also shown to reduce postischemic stunning (reversible
myocardial dysfunction) and reperfusion arrhythmias. There are two phases of
preconditioning, the first occurs within two hours after preconditioning and
the second appears between 24 to 96 hours after the initial phase (a second
window of protection). These two phases may have different signal pathways. In
the presented study the authors provide some evidence about the involvement of
IP3 signal pathway in the immediate preconditioning and suggest a potential
therapeutic approach to achieve preconditioning through this pathway.

McPharmNet - Molecular Pharmacology at McMaster /mcpharm@fhs.csu.mcmaster.ca/

Last revised May 7, 2000.

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