Clinical Epidemiology & Biostatistics
Janice Pogue
BA (York), MA (York), MSc (Queen's)Assistant Professor (Part-time), Department of Clinical Epidemiology & Biostatistics
Statistical Manager, Population Health Research Institute
905.527.4322 x 40340
905.527.5380
janice@phri.ca
Population Health Research Institute
McMaster Clinic
Hamilton General Hospital
237 Barton Street East
Hamilton, ON,
L8L 2X2
Academic Interests
Research interest include statistical issues related to clinical trials and meta-analysis. Directly involved in design and conduct of large-scale clinical trials in cardiovascular disease and in individual patient meta-analysis. Interested in issues related to Data and Safety Monitoring Boards and interim analysis of clinical trials.
Selected Publications
- Pogue J,. & Yusuf, S. Cumulating Data and Evidence from Trials: Utilizing Sequential Monitoring Boundaries for Cumulative Meta-Analysis. Controlled Clinical Trials 1997, 18, 580-593.
- Pogue J, Yusuf, S. Overcoming the Limitations of Current Meta-Analysis of Randomized Controlled Trials. The Lancet 1998, 351, 47-52.
- ACE-inhibitor Myocardial Infarction Collaborative Group. (Member of coordinating centre) Indication for ACE-inhibitors in the early treatment of acute myocardial infarction: systematic overview of individual data from 100,000 patients in randomized trials. Circulation 1998, 97, 2202-2212.
- The Heart Outcomes Prevention Evaluation Study Investigators.(member of manuscript writing group) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high- risk patients. New England J Medicine 2000, 342(3), 145-53.
- The Heart Outcomes Prevention Evaluation Study Investigators. (member of manuscript writing group). Vitamin E supplementaion and cardiovascular events in high-risk patients. New England J Medicine 2000, 342(3), 154-60.
- Pogue J, Yusuf S. Data Monitorint in the RESOLVD (Randomized Evaluation of Strategies for Left Ventricular Dysfunction) Pilot Study: when reasonable people disagreee. DeMets D, Furberg CD, Friedman LM. Data Monitoring in Clinical Trials: A Case Studies Approach. New York: Springer, 2006.
- Pogue J, Sackett D, Wyse DG, Yusuf S. Data monitoring in the Heart Outcomes Prevention Evaluation and Clopidogrel in Unstable Angina to prevent Recurrent ischemic Events trials: avoiding important information loss. DeMets D, Furberg CD, Friedman LM. Data Monitoring in Clinical Trials: A Case Studies Approach. New York: Springer, 2006.
- Pogue J, Walter SD, Yusuf S. Evaluating the Benefit of Event Adjudication of Cardiovascular Outcomes in Large Simple RCTs. Clinical Trials 2009; 6: 239-51.